Abstract
In conclusion, Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms. Perhaps through RNAi-related pathways or possibly also through distinct mechanisms, Argonaute family members have a variety of biological roles. These include regulation of development and determination of stem-cell character. Through an ever-advancing understanding of the biochemistry and genetics of the Argonaute family, we may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a variety of human diseases.
Keywords
BiologyArgonauteRNA interferenceCarcinogenesisCell biologyStem cellPiwi-interacting RNAGeneticsGeneRNA
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Publication Info
- Year
- 2002
- Type
- review
- Volume
- 16
- Issue
- 21
- Pages
- 2733-2742
- Citations
- 868
- Access
- Closed
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Cite This
Michelle A. Carmell,
Zhenyu Xuan,
Michael Q. Zhang
et al.
(2002).
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.
Genes & Development
, 16
(21)
, 2733-2742.
https://doi.org/10.1101/gad.1026102
Identifiers
- DOI
- 10.1101/gad.1026102