Abstract
The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1. Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders. These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2. A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3. Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6.
Keywords
Vascular endothelial growth factorBiologyVascular endothelial growth factor AGrowth factorVascular endothelial growth factor BVascular endothelial growth factor CCell biologyImmunologyVEGF receptorsCancer researchGenetics
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Publication Info
- Year
- 1997
- Type
- review
- Volume
- 18
- Issue
- 1
- Pages
- 4-25
- Citations
- 4344
- Access
- Closed
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Cite This
Napoleone Ferrara,
Terri Davis-Smyth
(1997).
The Biology of Vascular Endothelial Growth Factor.
Endocrine Reviews
, 18
(1)
, 4-25.
https://doi.org/10.1210/edrv.18.1.0287
Identifiers
- DOI
- 10.1210/edrv.18.1.0287