Abstract

Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.

Keywords

MedicineBreast cancerPathologicalRadiation therapyLymph nodeCancerOncologyClinical trialInternal medicineMammary glandPathology

MeSH Terms

AgedBreast NeoplasmsClinical Trials as TopicFemaleHumansLymph NodesMitosisNeoplasm RecurrenceLocalPrognosis

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Publication Info

Year
1982
Type
article
Volume
45
Issue
5
Pages
655-669
Citations
172
Access
Closed

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Cite This

C.W. Elston, G. A. Gresham, Gautam Rao et al. (1982). The cancer research campaign (King's/Cambridge trial for early breast cancer: Clinico-pathological aspects. British Journal of Cancer , 45 (5) , 655-669. https://doi.org/10.1038/bjc.1982.106

Identifiers

DOI
10.1038/bjc.1982.106
PMID
7044401
PMCID
PMC2011009

Data Quality

Data completeness: 86%