Abstract

The Carbohydrate-Active Enzymes database (CAZy; http://www.cazy.org) provides online and continuously updated access to a sequence-based family classification linking the sequence to the specificity and 3D structure of the enzymes that assemble, modify and breakdown oligo- and polysaccharides. Functional and 3D structural information is added and curated on a regular basis based on the available literature. In addition to the use of the database by enzymologists seeking curated information on CAZymes, the dissemination of a stable nomenclature for these enzymes is probably a major contribution of CAZy. The past few years have seen the expansion of the CAZy classification scheme to new families, the development of subfamilies in several families and the power of CAZy for the analysis of genomes and metagenomes. This article outlines the changes that have occurred in CAZy during the past 5 years and presents our novel effort to display the resolution and the carbohydrate ligands in crystallographic complexes of CAZymes.

Keywords

BiologyPhylogeneticsEvolutionary biologyDatabaseGeneticsGeneComputer science

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Publication Info

Year
2013
Type
article
Volume
42
Issue
D1
Pages
D490-D495
Citations
6182
Access
Closed

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Vincent Lombard, Hemalatha Golaconda Ramulu, Élodie Drula et al. (2013). The carbohydrate-active enzymes database (CAZy) in 2013. Nucleic Acids Research , 42 (D1) , D490-D495. https://doi.org/10.1093/nar/gkt1178

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DOI
10.1093/nar/gkt1178