The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme. Rationale, design and baseline characteristics including a...

Abstract

Randomized trials of thienopyridines in patients with vascular disease demonstrate that thienopyridines are effective in reducing vascular events when compared with placebo/control or aspirin, as well as when used in combination with aspirin in patients undergoing intracoronary stent implantation. The CURE trial is a large international study to determine if acute and long-term treatment with the combination of clopidogrel and aspirin is superior to aspirin alone in patients with acute coronary syndrome.

Keywords

MedicineClopidogrelMeta-analysisAnginaInternal medicineCardiologyUnstable anginaBaseline (sea)Stable anginaClinical trialCoronary artery diseaseAspirinIntensive care medicineMyocardial infarction

Affiliated Institutions

Hamilton Health Sciences CA

Related Publications

Benefits and Risks of the Combination of Clopidogrel and Aspirin in Patients Undergoing Surgical Revascularization for Non–ST-Elevation Acute Coronary Syndrome

Keith A.A. Fox , Shamir R. Mehta , Ron J.G. Peters +4 more

Background— Antiplatelet therapy and antithrombin therapy have been demonstrated to reduce the risk of cardiac events in patients presenting with acute coronary syndrome, yet al...

2004 Circulation 831 citations

Secondary prevention of vascular disease by prolonged antiplatelet treatment

Antiplatelet Trialists Collaboration

Thirty one randomised trials of antiplatelet treatment for patients with a history of transient ischaemic attack, occlusive stroke, unstable angina, or myocardial infarction wer...

1988 BMJ 998 citations

Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris

Steen Juul‐Möller , Nils Edvardsson , B Jahnmatz +3 more

Clinical trials have demonstrated a prophylactic role for aspirin in myocardial infarction and in unstable angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) is ...

1992 The Lancet 511 citations

Design of ESPRIT: An International Randomized Trial for Secondary Prevention after Non-Disabling Cerebral Ischaemia of Arterial Origin

E.L.L.M. De Schryver

The ESPRIT trial addresses the problem that aspirin, the standard therapy for secondary prevention of vascular complications after a transient ischaemic attack (TIA) or ischaemi...

2000 Cerebrovascular Diseases 98 citations

Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes

Stephen D. Wiviott , Eugene Braunwald , Carolyn H. McCabe +11 more

In patients with acute coronary syndromes with scheduled percutaneous coronary intervention, prasugrel therapy was associated with significantly reduced rates of ischemic events...

2007 New England Journal of Medicine 6636 citations

Publication Info

Year: 2000
Type: article
Volume: 21
Issue: 24
Pages: 2033-2041
Citations: 299
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme. Rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

299

OpenAlex

Cite This

APA Style

                            
                                
                                    Salim Yusuf, 
                                
                                    S Mehta, 
                                
                                    Shuchi Anand
                                
                                et al.
                            
                            (2000). 
                            The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme. Rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. 
                            European Heart Journal
                            , 21
                            (24)
                            , 2033-2041.
                            https://doi.org/10.1053/euhj.2000.2474
                        

Identifiers

DOI: 10.1053/euhj.2000.2474