Keywords
Current (fluid)RNA interferenceDrug discoveryComputational biologyState (computer science)PharmacologyMedicineComputer scienceBioinformaticsBiologyEngineeringGeneticsGeneAlgorithm
Affiliated Institutions
Related Publications
Therapeutic siRNA: state of the art
ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequenc...
Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution
This review article describes the current status and future perspectives of site-specific drug delivery by means of macromolecular carrier systems. Basic aspects and recent adva...
A microRNA in a Multiple-Turnover RNAi Enzyme Complex
In animals, the double-stranded RNA-specific endonuclease Dicer produces two classes of functionally distinct, tiny RNAs: microRNAs (miRNAs) and small interfering RNAs (siRNAs)....
Advances in oligonucleotide drug delivery
Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-codin...
Noncoding RNA therapeutics — challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of cancers, a...
Publication Info
- Year
- 2019
- Type
- review
- Volume
- 18
- Issue
- 6
- Pages
- 421-446
- Citations
- 1312
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1312
OpenAlex
Cite This
Ryan L. Setten,
John J. Rossi,
Si‐ping Han
(2019).
The current state and future directions of RNAi-based therapeutics.
Nature Reviews Drug Discovery
, 18
(6)
, 421-446.
https://doi.org/10.1038/s41573-019-0017-4
Identifiers
- DOI
- 10.1038/s41573-019-0017-4