The extent of non-adherence in a large AIDS clinical trial using plasma dideoxynucleoside concentrations as a marker

Abstract

Various non-adherence behaviors were observed, including patterns of underdosing and taking non-prescribed drugs. Non-adherence was moderate but uniform amongst the treatment groups and may have contributed to a marginal reduction in the power of the primary intent-to-treat analysis to detect differences in efficacy amongst the assigned treatments.

Keywords

MedicineZalcitabineDidanosineRegimenZidovudineDosingInternal medicineClinical trialRandomized controlled trialImmunologyHuman immunodeficiency virus (HIV)Viral disease

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Publication Info

Year: 1998
Type: article
Volume: 12
Issue: 17
Pages: 2305-2311
Citations: 61
Access: Closed

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APA Style

                            
                                
                                    Helen Kastrissios, 
                                
                                    José-Ramón Suárez, 
                                
                                    Scott Hammer
                                
                                et al.
                            
                            (1998). 
                            The extent of non-adherence in a large AIDS clinical trial using plasma dideoxynucleoside concentrations as a marker. 
                            AIDS
                            , 12
                            (17)
                            , 2305-2311.
                            https://doi.org/10.1097/00002030-199817000-00012
                        

Identifiers

DOI: 10.1097/00002030-199817000-00012