Abstract

The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.

Keywords

Keratinocyte growth factorWound healingKeratinocyteCell biologyMorphogenesisTransgeneEpidermal growth factor receptorBiologyEpitheliumHair follicleBasal (medicine)ReceptorAtrophyEpidermal growth factorPathologyGrowth factorEndocrinologyMedicineImmunologyIn vitroGeneBiochemistry

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Publication Info

Year
1994
Type
article
Volume
266
Issue
5186
Pages
819-822
Citations
597
Access
Closed

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Sabine Werner, Hans Smola, Xiang Liao et al. (1994). The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds. Science , 266 (5186) , 819-822. https://doi.org/10.1126/science.7973639

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DOI
10.1126/science.7973639