The Genome Sequence of the SARS-Associated Coronavirus

Abstract

We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)âassociated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.

Keywords

VirologyBiologyCoronavirusGenomeVirusPhylogenetic treeWhole genome sequencingPolymerase chain reactionCoronaviridaeGeneSequence analysisGeneticsCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)MedicineDisease

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Publication Info

Year: 2003
Type: article
Volume: 300
Issue: 5624
Pages: 1399-1404
Citations: 2075
Access: Closed

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APA Style

                            
                                
                                    Marco A. Marra, 
                                
                                    Steven J.M. Jones, 
                                
                                    Caroline R. Astell
                                
                                et al.
                            
                            (2003). 
                            The Genome Sequence of the SARS-Associated Coronavirus. 
                            Science
                            , 300
                            (5624)
                            , 1399-1404.
                            https://doi.org/10.1126/science.1085953
                        

Identifiers

DOI: 10.1126/science.1085953