Abstract
The Intronerator (http://www.cse.ucsc.edu/ approximately kent/intronerator/ ) is a set of web-based tools for exploring RNA splicing and gene structure in Caenorhabditis elegans. It includes a display of cDNA alignments with the genomic sequence, a catalog of alternatively spliced genes and a database of introns. The cDNA alignments include >100 000 ESTs and almost 1000 full-length cDNAs. ESTs from embryos and mixed stage animals as well as full-length cDNAs can be compared in the alignment display with each other and with predicted genes. The alt-splicing catalog includes 844 open reading frames for which there is evidence of alternative splicing of pre-mRNA. The intron database includes 28 478 introns, and can be searched for patterns near the splice junctions.
Keywords
BiologyIntronRNA splicingCaenorhabditis elegansGeneticsExpressed sequence tagCaenorhabditisGeneComplementary DNAAlternative splicingExonComputational biologyRNA
Affiliated Institutions
Related Publications
Structural diversity and functional implications of the eukaryotic TDP gene family
TDP-43 is an RNA-binding protein that functions in mammalian cells in transcriptional repression and exon skipping. The gene encoding TDP-43 (HGMW-approved gene symbol TARDBP) i...
Comparative Analysis of Amino Acid Usage and Protein Length Distribution Between Alternatively and Non-alternatively Spliced Genes Across Six Eukaryotic Genomes
Alternative splicing has been discovered in nearly all metazoan organisms as a mechanism to increase the diversity of gene products. However, the origin and evolution of alterna...
Alternative isoform regulation in human tissue transcriptomes
Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposin...
Noisy Splicing Drives mRNA Isoform Diversity in Human Cells
While the majority of multiexonic human genes show some evidence of alternative splicing, it is unclear what fraction of observed splice forms is functionally relevant. In this ...
Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing
Besides linear RNAs, pre-mRNA splicing generates three forms of RNAs: lariat introns, Y-structure introns from trans-splicing, and circular exons through exon skipping. To study...
Publication Info
- Year
- 2000
- Type
- article
- Volume
- 28
- Issue
- 1
- Pages
- 91-93
- Citations
- 90
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
90
OpenAlex
Cite This
W. James Kent
(2000).
The Intronerator: exploring introns and alternative splicing in Caenorhabditis elegans.
Nucleic Acids Research
, 28
(1)
, 91-93.
https://doi.org/10.1093/nar/28.1.91
Identifiers
- DOI
- 10.1093/nar/28.1.91