The JAK/STAT signaling pathway: from bench to clinic

Xiaoyi Hu; Jing Li; Maorong Fu; Xia Zhao; Wei Wang

doi:10.1038/s41392-021-00791-1

Abstract

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.

Keywords

statJAK-STAT signaling pathwaySignal transductionMedicineBench to bedsideCancer researchImmunologyCell biologyBiologyMedical physicsTyrosine kinase

MeSH Terms

Autoimmune DiseasesHumansJanus KinasesNeoplasm ProteinsNeoplasmsSTAT Transcription FactorsSignal Transduction

Affiliated Institutions

Sichuan University CN

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Publication Info

Year: 2021
Type: review
Volume: 6
Issue: 1
Pages: 402-402
Citations: 2056
Access: Closed

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APA Style

                            
                                
                                    Xiaoyi Hu, 
                                
                                    Jing Li, 
                                
                                    Maorong Fu
                                
                                et al.
                            
                            (2021). 
                            The JAK/STAT signaling pathway: from bench to clinic. 
                            Signal Transduction and Targeted Therapy
                            , 6
                            (1)
                            , 402-402.
                            https://doi.org/10.1038/s41392-021-00791-1
                        

Identifiers

DOI: 10.1038/s41392-021-00791-1
PMID: 34824210
PMCID: PMC8617206

Data Quality

Data completeness: 90%