The Minimal Gene Complement of Mycoplasma genitalium

Abstract

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.

Keywords

Mycoplasma genitaliumGenomeBiologyGeneGeneticsMollicutesDNADNA sequencingWhole genome sequencingBase pairMycoplasmaVirology

MeSH Terms

Antigenic VariationBacterial ProteinsBiological TransportDNA RepairDNA ReplicationDNABacterialDatabasesFactualEnergy MetabolismGenesBacterialGenomeBacterialHaemophilus influenzaeMolecular Sequence DataMycoplasmaOpen Reading FramesProtein BiosynthesisSequence AnalysisDNATranscriptionGenetic

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Publication Info

Year: 1995
Type: article
Volume: 270
Issue: 5235
Pages: 397-404
Citations: 2507
Access: Closed

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APA Style

                            
                                
                                    Claire M. Fraser, 
                                
                                    Jeannine D. Gocayne, 
                                
                                    Owen White
                                
                                et al.
                            
                            (1995). 
                            The Minimal Gene Complement of <i>Mycoplasma genitalium</i>. 
                            Science
                            , 270
                            (5235)
                            , 397-404.
                            https://doi.org/10.1126/science.270.5235.397
                        

Identifiers

DOI: 10.1126/science.270.5235.397
PMID: 7569993

Data Quality

Data completeness: 81%