The molecular architecture of severe pediatric traumatic brain injury: integrated omics reveal therapeutic pathways

Elora Hussain; Jeremy W. Prokop; Emily Nonnemacher; Nadia Ashrafi; Ali Yılmaz; Khalid Abdullah; Vilija Lomeikaite; Louis J. Sanfilippo; Jacob Charron; Charitha Subrahmanya; Annie Needs; Daniel Woldring; Caleb Bupp; Juozas Gordevičius; Surender Rajasekaran

doi:10.1186/s13054-025-05789-7

Abstract

Despite the heterogeneity in injury mechanisms and clinical presentations, our findings reveal a convergent host response, characterized by shared transcriptomic and metabolic signatures across all time points. This convergence highlights potentially targetable biological pathways and opens the door to the development of novel therapeutic strategies for severe pediatric TBI.

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Year: 2025
Type: article
Citations: 0
Access: Closed

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APA Style

                            
                                    Elora Hussain, 
                                
                                    Jeremy W. Prokop, 
                                
                                    Emily Nonnemacher
                                
                                et al.
                            
                            (2025). 
                            The molecular architecture of severe pediatric traumatic brain injury: integrated omics reveal therapeutic pathways. 
                            Critical Care
                            
                            .
                            https://doi.org/10.1186/s13054-025-05789-7

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DOI: 10.1186/s13054-025-05789-7