The Prediction of Bradykinin Potentiating Potency of Pentapeptides. An Example of a Peptide Quantitative Structure-activity Relationship.

Abstract

The variation in amino acid sequence, in a set of bradykinin potentiating pentapeptides, is described by three variables per amino acid position. The variables were derived from a principal components analysis of a property matrix for the 20 coded amino acids. The resulting structure descriptor matrix describes the observed activity of the peptides to 97% by means of a multivariate partial least squares (PLS) model. It is demonstrated that this quantitative structure-activity relationship (QSAR) can be used to predict the activity of new peptide analogs.

Keywords

ChemistryQuantitative structure–activity relationshipPartial least squares regressionBradykininPeptideAmino acidStereochemistryDipeptideMatrix (chemical analysis)Amino acid residuePeptide sequenceBiochemistryChromatographyMathematics

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Publication Info

Year: 1986
Type: article
Volume: 40b
Issue: 2
Pages: 135-140
Citations: 123
Access: Closed

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APA Style

                            
                                
                                    Sven Hellberg, 
                                
                                    Michael Sjöstróm, 
                                
                                    Svante Wold
                                
                                et al.
                            
                            (1986). 
                            The Prediction of Bradykinin Potentiating Potency of Pentapeptides. An Example of a Peptide Quantitative Structure-activity Relationship.. 
                            Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry
                            , 40b
                            (2)
                            , 135-140.
                            https://doi.org/10.3891/acta.chem.scand.40b-0135
                        

Identifiers

DOI: 10.3891/acta.chem.scand.40b-0135