The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer

Abstract

Patients with extreme p53 IHC expression have a worse OS than those with NE expression. Accounting for EN as well as EP expression improves the prognostic impact. Extreme expression positively correlates with nodal stage and histological grade, and negatively with hormone receptor status. Extreme expression may relate to specific mutational status.

Keywords

ImmunohistochemistryImmunophenotypingTissue microarrayUnivariate analysisMissense mutationBreast cancerOncologyPhenotypeBiologyMultivariate analysisInternal medicinePathologyCancer researchMedicineCancerGeneGeneticsFlow cytometry

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Publication Info

Year: 2014
Type: article
Volume: 65
Issue: 3
Pages: 340-352
Citations: 65
Access: Closed

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APA Style

                            
                                
                                    David P. Boyle, 
                                
                                    Darragh G. McArt, 
                                
                                    Gareth Irwin
                                
                                et al.
                            
                            (2014). 
                            The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer. 
                            Histopathology
                            , 65
                            (3)
                            , 340-352.
                            https://doi.org/10.1111/his.12398
                        

Identifiers

DOI: 10.1111/his.12398