The Reactome pathway knowledgebase

David Croft; Antonio Fabregat; Robin Haw; M Orlic-Milacic; Joel Weiser; Guanming Wu; Michael Caudy; Phani Garapati; Marc Gillespie; Maulik R. Kamdar; Bijay Jassal; S Jupe; Lisa Matthews; Bruce May; Stanislav Palatnik; Karen Rothfels; Veronica Shamovsky; Heeyeon Song; Mark Williams; Ewan Birney; Henning Hermjakob; Lincoln Stein; Peter D’Eustachio

doi:10.1093/nar/gkt1102

Abstract

Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.

Keywords

BiologyAnnotationComputational biologyProteomeHuman proteome projectHuman diseaseComputer scienceBioinformaticsGeneticsProteomicsGene

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Publication Info

Year: 2013
Type: article
Volume: 42
Issue: D1
Pages: D472-D477
Citations: 1941
Access: Closed

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APA Style

                            
                                
                                    David Croft, 
                                
                                    Antonio Fabregat, 
                                
                                    Robin Haw
                                
                                et al.
                            
                            (2013). 
                            The Reactome pathway knowledgebase. 
                            Nucleic Acids Research
                            , 42
                            (D1)
                            , D472-D477.
                            https://doi.org/10.1093/nar/gkt1102
                        

Identifiers

DOI: 10.1093/nar/gkt1102