The Reactome pathway Knowledgebase

Antonio Fabregat; Konstantinos Sidiropoulos; Phani Garapati; Marc Gillespie; Kerstin Hausmann; Robin Haw; Bijay Jassal; S Jupe; Florian Korninger; Sheldon McKay; Lisa Matthews; Bruce May; M Orlic-Milacic; Karen Rothfels; Veronica Shamovsky; Marissa Webber; Joel Weiser; Mark Williams; Guanming Wu; Lincoln Stein; Henning Hermjakob; Peter D’Eustachio

doi:10.1093/nar/gkv1351

Abstract

This FAIRsharing record describes: The cornerstone of Reactome is a freely available, open source relational database of signaling and metabolic molecules and their relations organized into biological pathways and processes. The core unit of the Reactome data model is the reaction. Entities (nucleic acids, proteins, complexes, vaccines, anti-cancer therapeutics and small molecules) participating in reactions form a network of biological interactions and are grouped into pathways. Examples of biological pathways in Reactome include classical intermediary metabolism, signaling, transcriptional regulation, apoptosis and disease. Inferred orthologous reactions are available for 15 non-human species including mouse, rat, chicken, zebrafish, worm, fly, and yeast.

Keywords

VisualizationInterface (matter)Computer scienceBiologyZoomData visualizationUser interfaceComputational biologyThe InternetUsabilityGraph drawingInformation retrievalData miningBioinformaticsWorld Wide WebHuman–computer interactionProgramming language

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Publication Info

Year: 2015
Type: article
Volume: 44
Issue: D1
Pages: D481-D487
Citations: 5993
Access: Closed

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APA Style

                            
                                
                                    Antonio Fabregat, 
                                
                                    Konstantinos Sidiropoulos, 
                                
                                    Phani Garapati
                                
                                et al.
                            
                            (2015). 
                            The Reactome pathway Knowledgebase. 
                            Nucleic Acids Research
                            , 44
                            (D1)
                            , D481-D487.
                            https://doi.org/10.1093/nar/gkv1351
                        

Identifiers

DOI: 10.1093/nar/gkv1351