Abstract
Abstract Already in 1939 and 1945 it had been demonstrated that tumours induce the formation of new capillaries from preexisting blood vessels, a process termed angiogenesis (1,2). Subsequently, it was shown that soluble angiogenic factors released by tumours were responsible for this process (3,4). The finding that many of these growth factors bound to heparin allowed the purification and classification of a family of heparin-binding growth factors (5). The prototypes of this family are fibroblast growth factor (FGF) 1 and FGF-2, and they have been studied in great detail in many physiological and pathological processes (reviewed in references 6-10). To date the family has expanded to nine distinct, but closely related family members. Based on their pattern of expression and their biological activities they are thought to be involved in many physiological and pathological processes, including embryonic development, differentiation, cell survival, angiogenesis, oncogenic transformation, and tumour cell proliferation.
Keywords
AngiogenesisFibroblast growth factorBiologyPathologicalCancer researchCell biologyEmbryonic stem cellCell growthFibroblastHeparinBasic fibroblast growth factorGrowth factorImmunologyPathologyMedicineCell cultureGeneticsBiochemistryReceptorGene
Related Publications
Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction
The fibroblast growth factors are a family of structurally related polypeptides that are mitogenic for a broad range of cell types as well as mediators of a wide spectrum of dev...
Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies
Abstract Embryonic stem cells (ESC) have been established previously from the inner cell mass cells of mouse blastocysts. In suspension culture, they spontaneously differentiate...
Peptide growth factors in the intestine
A continuously increasing number of regulatory peptides has been demonstrated to be expressed in the intestine and to modulate several functional properties of various intestina...
Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours
Tumour growth is angiogenesis-dependent; brain tumours have more intense neovascularisation than other tumours and produce basic fibroblast growth factor, a potent angiogenic me...
Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response
Salt extracts of the extracellular matrix (ECM) that is produced by vascular and capillary endothelial cells contain mitogens that are indistinguishable from basic and acidic fi...
Publication Info
- Year
- 1997
- Type
- book-chapter
- Pages
- 201-238
- Citations
- 13
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
13
OpenAlex
11
CrossRef
Cite This
Gerhard Christofori
(1997).
The role of fibroblast growth factors in tumour progression and angiogenesis.
Tumour Angiogenesis
, 201-238.
https://doi.org/10.1093/oso/9780198549376.003.0017
Identifiers
- DOI
- 10.1093/oso/9780198549376.003.0017