Abstract
Resiniferatoxin, an extremely irritant diterpene present in several members of the genus Euphorbia, produced an 8 C decrease in the rectal temperature of mice with an effective dose in the range of 2-20 micrograms/kg. The structurally related natural product capsaicin produced a similar magnitude of fall in body temperature, albeit with 1000-fold lower potency. Tolerance to the hypothermic effects of both compounds readily developed and cross-tolerance between the compounds was observed. The extreme potency of resiniferatoxin should facilitate biochemical analysis of the mechanism of action of this class of compounds.
Keywords
ResiniferatoxinCapsaicinPotencyChemistryPharmacologyNatural productDiterpeneRectal temperatureStereochemistryBiologyAnesthesiaBiochemistryMedicineIn vitro
MeSH Terms
AnimalsBody TemperatureCapsaicinDiterpenesDose-Response RelationshipDrugDrug ToleranceFemaleMice
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Publication Info
- Year
- 1989
- Type
- article
- Volume
- 44
- Issue
- 11
- Pages
- 711-715
- Citations
- 71
- Access
- Closed
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Cite This
David J. De Vries,
Peter M. Blumberg
(1989).
Thermoregulatory effects of resiniferatoxin in the mouse: Comparison with capsaicin.
Life Sciences
, 44
(11)
, 711-715.
https://doi.org/10.1016/0024-3205(89)90382-2
Identifiers
- DOI
- 10.1016/0024-3205(89)90382-2
- PMID
- 2927241