Three-dimensional Structure of Tosyl-α-chymotrypsin

Keywords

ChymotrypsinChemistryTosylStereochemistryActive siteProtein tertiary structureMoleculeEnzymeResolution (logic)Amino acidSequence (biology)Protein structureCrystallographyBiochemistryOrganic chemistryTrypsin

Affiliated Institutions

MRC Laboratory of Molecular Biology GB

Related Publications

The structural enzymology of proton-transfer reactions

Gregory A. Petsko , Dagmar Ringe , Karen N. Allen +15 more

The simplest chemical transformations in metabolism are the proton transfer reactions exemplified by certain isomerases and racemases. We have been studying three such enzymes t...

1993 Protein Engineering Design and Selection 43 citations

Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES

Manfred Eigen

Abstract The proton occupies a special position as a promoter and mediator in chemical reactions occurring in solution. Many reactions in organic chemistry are catalysed by acid...

1964 Angewandte Chemie International Editi... 1792 citations

Dissecting protein–protein recognition sites

Pinak Chakrabarti , Joël Janin

Abstract The recognition sites in 70 pairwise protein–protein complexes of known three‐dimensional structure are dissected in a set of surface patches by clustering atoms at the...

2002 Proteins Structure Function and Bioin... 570 citations

On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands

Eduardo A. Padlan

Abstract A detailed analysis of the structural aspects of antibody–antigen interactions has been made possible by the availability of X‐ray structures for three complexes of ant...

1990 Proteins Structure Function and Bioin... 230 citations

Simulations of Nanocylinders Self-Assembled from Cyclic β-Tripeptides

Noam Bernstein , John L. Kulp , Michael A. Cato +1 more

This paper examines the self-assembly of cyclic β-tripeptides using density functional theory. On the basis of literature precedents, these cyclic peptides were expected to self...

2010 The Journal of Physical Chemistry A 5 citations

Publication Info

Year: 1967
Type: article
Volume: 214
Issue: 5089
Pages: 652-656
Citations: 613
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Three-dimensional Structure of Tosyl-α-chymotrypsin

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

613

OpenAlex

Cite This

APA Style

                            
                                
                                    Brian W. Matthews, 
                                
                                    Paul B. Sigler, 
                                
                                    Richard A. Henderson
                                
                                et al.
                            
                            (1967). 
                            Three-dimensional Structure of Tosyl-α-chymotrypsin. 
                            Nature
                            , 214
                            (5089)
                            , 652-656.
                            https://doi.org/10.1038/214652a0
                        

Identifiers

DOI: 10.1038/214652a0