Thrombin, Thrombomodulin and TAFI in the Molecular Link Between Coagulation and Fibrinolysis

Michael E. Nesheim; Wei Wang; Michael B. Boffa; Mariko Nagashima; John Morser; Laszlo Bajzar

doi:10.1055/s-0038-1657557

Abstract

The thrombin thrombomodulin dependent activation of the plasma protein TAFI (Thrombin Activatable Fibrinolysis Inhibitor) and Subsequent Inhibition of Fibrinolysis by the TAFIa is described. Work to date indicates that TAFIa is a carboxypeptidase B enzyme that suppress fibrinolysis most likely by down regulating the cofactor functions of partially degraded fibrin. The existence of TAFI provides the explanation for the apparent profibrinolytic effect of activated protein C. and implies the existence of an explicit molecular connection between the blood coagulation of fibrinolytic cascades that is expressed through the thrombin thrombomodulin dependent activation of TAFI. Thus, thrombin generation can, in principle, result in the suppression of fibrinolysis.

Keywords

ThrombomodulinFibrinolysisThrombinFibrinCoagulationCarboxypeptidaseProtein CChemistryProthrombinaseBiochemistryMedicineEnzymeImmunologyInternal medicinePlatelet

Affiliated Institutions

Queen's University CA

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Publication Info

Year: 1997
Type: article
Volume: 78
Issue: 01
Pages: 386-391
Citations: 261
Access: Closed

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APA Style

                            
                                
                                    Michael E. Nesheim, 
                                
                                    Wei Wang, 
                                
                                    Michael B. Boffa
                                
                                et al.
                            
                            (1997). 
                            Thrombin, Thrombomodulin and TAFI in the Molecular Link Between Coagulation and Fibrinolysis. 
                            Thrombosis and Haemostasis
                            , 78
                            (01)
                            , 386-391.
                            https://doi.org/10.1055/s-0038-1657557
                        

Identifiers

DOI: 10.1055/s-0038-1657557