Keywords
Protein kinase BPI3K/AKT/mTOR pathwayBiologyProgrammed cell deathSignal transductionTranscription factorCell biologyCell survivalGeneApoptosisGenetics
Affiliated Institutions
Related Publications
Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-...
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
Serum and certain growth factors have the ability to inhibit programmed cell death (apoptosis) and promote survival. The mechanism by which growth factors deliver an anti-apopto...
Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival
The serine/threonine kinase Akt (also known as protein kinase B) is activated in response to various stimuli by a mechanism involving phosphoinositide 3-kinase (PI3-K). Akt prov...
Autophagy and autophagy-related proteins in cancer
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progress...
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase...
Publication Info
- Year
- 2001
- Type
- review
- Volume
- 11
- Issue
- 3
- Pages
- 297-305
- Citations
- 1177
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1177
OpenAlex
Cite This
Anne Brunet,
Sandeep Robert Datta,
Michael E. Greenberg
(2001).
Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway.
Current Opinion in Neurobiology
, 11
(3)
, 297-305.
https://doi.org/10.1016/s0959-4388(00)00211-7
Identifiers
- DOI
- 10.1016/s0959-4388(00)00211-7