Abstract

Twenty-two patients who had an episode of transfusion-associated hepatitis not positive for hepatitis B antigen were examined for development of antibody to heaptitis A and B antigens, cytomegalovirus and Epstein-Barr virus. Antibody response to the 27-nm virus-like hepatitis A antigen was measured by immune electron microscopy. In none of the 22 patients studied did serologic evidence of infection with hepatitis A virus develop during the study period. Nine of the 22 patients had antibody responses to cytomegalovirus, but it was difficult to relate these seroconversions to their hepatitis. In addition, all 22 patients had pre-existing antibody to the Epstein-Barr virus. It seems likely that at least a proportion of such antigen-negative transfusion-associated hepatitis is caused by other infectious agents, not yet identified.

Keywords

MedicineVirologyCytomegalovirusHepatitisImmunologyAntibodyAntigenVirusHepatitis B virusHepatitis ASerologyHepatitis BHepatitis C virusViral diseaseHerpesviridae

MeSH Terms

AntibodiesViralCytomegalovirusHepatitis A AntibodiesHepatitis AntibodiesHepatitis B AntibodiesHepatitis B Surface AntigensHepatitisViralHumanHerpesvirus 4HumanHistory20th CenturyHumansMicroscopyImmunoelectronTransfusion Reaction

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Publication Info

Year
1975
Type
article
Volume
292
Issue
15
Pages
767-770
Citations
659
Access
Closed

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Cite This

Stephen M. Feinstone, Albert Z. Kapikian, Robert H. Purcell et al. (1975). Transfusion-Associated Hepatitis Not Due to Viral Hepatitis Type A or B. New England Journal of Medicine , 292 (15) , 767-770. https://doi.org/10.1056/nejm197504102921502

Identifiers

DOI
10.1056/nejm197504102921502
PMID
11241798

Data Quality

Data completeness: 81%