Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler; W. Taylor Kimberly; Beth L. Ostaszewski; Thekla S. Diehl; Chad L. Moore; Jui-Yi Tsai; Talat Rahmati; Weiming Xia; Dennis J. Selkoe; Michael S. Wolfe

doi:10.1038/35017062

Keywords

PresenilinAmyloid precursor protein secretaseAlpha secretaseAmyloid precursor proteinGamma secretaseNotch signaling pathwayTransmembrane proteinProteolysisNicastrinCell biologyChemistryPathogenesisBiologyBiochemistryAlzheimer's diseaseNeuroscienceReceptorSignal transductionDiseaseEnzymeMedicineImmunologyInternal medicine

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Publication Info

Year: 2000
Type: article
Volume: 2
Issue: 7
Pages: 428-434
Citations: 517
Access: Closed

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APA Style

                            
                                
                                    William P. Esler, 
                                
                                    W. Taylor Kimberly, 
                                
                                    Beth L. Ostaszewski
                                
                                et al.
                            
                            (2000). 
                            Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1. 
                            Nature Cell Biology
                            , 2
                            (7)
                            , 428-434.
                            https://doi.org/10.1038/35017062
                        

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DOI: 10.1038/35017062