Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer’s Association Reserve, Resilience and Protective Factors Professional Interest Area working groups

Abstract

There is an urgent need to advance our concept of reserve from a hypothetical model to a more concrete approach that can be used to improve the development of effective interventions aimed at preventing dementia. Our group recommends agreement on a common dictionary of terms referring to different aspects of reserve, the improvement of opportunities for data sharing across individual cohorts, harmonising research approaches across laboratories and groups to reduce heterogeneity associated with human data, global coordination of clinical trials to more effectively explore whether reducing epidemiological risk factors leads to a reduced burden of neurodegenerative diseases in the population, and an increase in our understanding of the appropriateness of animal models for reserve research.

Keywords

Affiliated Institutions

• Université de Caen Normandie FR
• Columbia University Irving Medical Center US
• LMU Klinikum DE
• Tel Aviv University IL
• Inserm FR
• Eginition Hospital GR
• Erasmus MC NL
• Ludwig-Maximilians-Universität München DE
• National and Kapodistrian University of Athens GR
• Cyceron FR
• German Center for Neurodegenerative Diseases DE
• Newcastle University GB

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