Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

W. Cameron Black; Christopher I. Bayly; Dana Davis; Sylvie Desmarais; Jean‐Pierre Falgueyret; Serge Léger; Chun Sing Li; Frédéric Massé; Daniel J. McKay; James T. Palmer; M. David Percival; Joël Robichaud; Nancy N. Tsou; Robert Zamboni

doi:10.1016/j.bmcl.2005.07.071

Keywords

ChemistryDipeptideAmideCathepsin SCathepsinStereochemistryPeptide bondSelectivityEnzyme inhibitorCarboxamideChemical synthesisCathepsin KNitrogen atomHydrogen bondCathepsin BPeptideEnzymeBiochemistryIn vitroOrganic chemistryMoleculeGroup (periodic table)Catalysis

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Publication Info

Year: 2005
Type: article
Volume: 15
Issue: 21
Pages: 4741-4744
Citations: 135
Access: Closed

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APA Style

                            
                                
                                    W. Cameron Black, 
                                
                                    Christopher I. Bayly, 
                                
                                    Dana Davis
                                
                                et al.
                            
                            (2005). 
                            Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. 
                            Bioorganic & Medicinal Chemistry Letters
                            , 15
                            (21)
                            , 4741-4744.
                            https://doi.org/10.1016/j.bmcl.2005.07.071
                        

Identifiers

DOI: 10.1016/j.bmcl.2005.07.071