Abstract

THE growth of solid neoplasms is always accompanied by neovascularization. This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in fresh wounds or in inflammation.1 Many workers have described the association between growing solid malignant tumors and new vessel growth.2 3 4 5 6 However, it has not been appreciated until the past few years that the population of tumor cells and the population of capillary endothelial cells within a neoplasm may constitute a highly integrated ecosystem. In this ecosystem the mitotic index of the two cell populations may depend upon each other. Tumor cells . . .

Keywords

NeovascularizationAngiogenesisMedicinePopulationMitotic indexInflammationMitosisCancer researchPathologyImmunologyCell biologyBiology

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Publication Info

Year
1971
Type
review
Volume
285
Issue
21
Pages
1182-1186
Citations
10030
Access
Closed

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Louis M. Sherwood, Edith E. Parris, Judah Folkman (1971). Tumor Angiogenesis: Therapeutic Implications. New England Journal of Medicine , 285 (21) , 1182-1186. https://doi.org/10.1056/nejm197111182852108

Identifiers

DOI
10.1056/nejm197111182852108