Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Abstract

Tissue macrophages have a split personality Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues. Science , this issue p. eaau0964 ; see also p. 1154

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Affiliated Institutions

• Centre National de la Recherche Scientifique FR
• University of Bonn DE
• Kyoto University JP
• University of Liège BE
• Centre d'Immunophénomique
• Inserm FR
• Agency for Science, Technology and Research SG
• Walloon Excellence in Lifesciences and Biotechnology BE
• Aix-Marseille Université FR
• National University of Singapore SG
• Singapore Immunology Network SG
• Centre d’Immunologie de Marseille-Luminy FR

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