Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with <i>neu</i> Oncogene

Lisa M. Coussens; Teresa L. Yang‐Feng; Yu-Cheng Liao; Ellson Chen; Alane Gray; John P. McGrath; Peter H. Seeburg; Towia A. Libermann; Joseph Schlessinger; Uta Francke; Arthur D. Levinson; Axel Ullrich

doi:10.1126/science.2999974

Abstract

A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene product; the chromosomal location of the gene for this protein is coincident with the neu oncogene, which suggests that the two genes may be identical.

Keywords

ROR1Receptor tyrosine kinaseErbBTropomyosin receptor kinase CTyrosine kinaseBiologyCancer researchEpidermal growth factorInterleukin-21 receptorMolecular biologyGrowth factor receptorReceptor Protein-Tyrosine KinasesGenePlatelet-derived growth factor receptorReceptorGeneticsGrowth factor

Affiliated Institutions

Related Publications

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

Louis M. Luttrell , Gregory J. Della Rocca , Tim van Biesen +2 more

In many cells, stimulation of mitogen-activated protein kinases by both receptor tyrosine kinases and receptors that couple to pertussis toxin-sensitive heterotrimeric G protein...

1997 Journal of Biological Chemistry 457 citations

ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

Monilola A. Olayioye , Diana Graus-Porta , Roger R. Beerli +3 more

The different epidermal growth factor (EGF)-related peptides elicit a diverse array of biological responses as the result of their ability to activate distinct subsets of ErbB r...

1998 Molecular and Cellular Biology 257 citations

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

Paolo Fedi , Jacalyn H. Pierce , Pier Paolo Di Fiore +1 more

Recombinant expression of a chimeric EGFR/ErbB-3 receptor in NIH 3T3 fibroblasts allowed us to investigate cytoplasmic events associated with ErbB-3 signal transduction upon lig...

1994 Molecular and Cellular Biology 229 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

H. Yamazaki , Yoshinori Fukui , Yoshito Ueyama +4 more

By using Southern blot analysis, we found that in two cases of human glioblastoma multiforme, cells carried amplified c-erbB genes which bore short deletion mutations within the...

1988 Molecular and Cellular Biology 214 citations

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand

Samuel Bouyain , Patti A. Longo , Shiqing Li +2 more

The human ErbB family of receptor tyrosine kinases comprises the epidermal growth factor receptor (EGFR/ErbB1/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). ErbBs play...

2005 Proceedings of the National Academy o... 188 citations

Publication Info

Year: 1985
Type: article
Volume: 230
Issue: 4730
Pages: 1132-1139
Citations: 1789
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with <i>neu</i> Oncogene

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1789

OpenAlex

Cite This

APA Style

                            
                                
                                    Lisa M. Coussens, 
                                
                                    Teresa L. Yang‐Feng, 
                                
                                    Yu-Cheng Liao
                                
                                et al.
                            
                            (1985). 
                            Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with <i>neu</i> Oncogene. 
                            Science
                            , 230
                            (4730)
                            , 1132-1139.
                            https://doi.org/10.1126/science.2999974
                        

Identifiers

DOI: 10.1126/science.2999974