Up-Regulation of PD-L1, IDO, and T regs in the Melanoma Tumor Microenvironment Is Driven by CD8 + T Cells

Abstract

CD8 + T cells induce immunosuppressive mechanisms in the tumor microenvironment.

Keywords

Tumor microenvironmentFOXP3Immune systemCytotoxic T cellImmunotherapyCD8Cancer researchT cellCancer immunotherapyChemokineBiologyImmunologyMelanomaCell biologyIn vitro

Affiliated Institutions

University of Chicago US

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Publication Info

Year: 2013
Type: article
Volume: 5
Issue: 200
Pages: 200ra116-200ra116
Citations: 1639
Access: Closed

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APA Style

                            
                                
                                    Stefani Spranger, 
                                
                                    Robbert M. Spaapen, 
                                
                                    Yuanyuan Zha
                                
                                et al.
                            
                            (2013). 
                            Up-Regulation of PD-L1, IDO, and T <sub>regs</sub> in the Melanoma Tumor Microenvironment Is Driven by CD8 <sup>+</sup> T Cells. 
                            Science Translational Medicine
                            , 5
                            (200)
                            , 200ra116-200ra116.
                            https://doi.org/10.1126/scitranslmed.3006504
                        

Identifiers

DOI: 10.1126/scitranslmed.3006504

Up-Regulation of PD-L1, IDO, and T <sub>regs</sub> in the Melanoma Tumor Microenvironment Is Driven by CD8 <sup>+</sup> T Cells