Urine Free Cortisol in the High-Dose Dexamethasone Suppression Test for the Differential Diagnosis of the Cushing Syndrome

Mary R. Flack; Edward H. Oldfield; Gordon B. Cutler; M H Zweig; James D. Malley; George P. Chrousos; D. Lynn Loriaux; Lynnette K. Nieman

doi:10.7326/0003-4819-116-3-211

Abstract

In the high-dose dexamethasone suppression test, the degree of suppression of urine free cortisol used for the diagnosis of pituitary disease is greater than that traditionally used for 17-hydroxysteroid excretion. The diagnostic performance of the test is improved by measuring both urine free cortisol and 17-hydroxysteroid excretion and by requiring greater suppression of both steroids.

Keywords

MedicineDexamethasone suppression testUrineInternal medicineEndocrinologyDexamethasoneExcretionCushing syndromeHydrocortisoneAdrenocorticotropic hormoneHormoneGastroenterology

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Publication Info

Year: 1992
Type: article
Volume: 116
Issue: 3
Pages: 211-217
Citations: 167
Access: Closed

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APA Style

                            
                                
                                    Mary R. Flack, 
                                
                                    Edward H. Oldfield, 
                                
                                    Gordon B. Cutler
                                
                                et al.
                            
                            (1992). 
                            Urine Free Cortisol in the High-Dose Dexamethasone Suppression Test for the Differential Diagnosis of the Cushing Syndrome. 
                            Annals of Internal Medicine
                            , 116
                            (3)
                            , 211-217.
                            https://doi.org/10.7326/0003-4819-116-3-211
                        

Identifiers

DOI: 10.7326/0003-4819-116-3-211