Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

Abstract

Some interventions on HDL-c concentrations may influence risk of CAD, but to a lesser extent than interventions on LDL-c. A causal interpretation of these estimates relies on the assumption that the genetic variants do not have pleiotropic associations with risk factors on other pathways to CAD. If they do, a weaker conclusion is that genetic predictors of LDL-c, HDL-c and triglycerides each have independent associations with CAD risk.

Keywords

Mendelian randomizationInternal medicineCholesterolCoronary artery diseaseOdds ratioLipoproteinMedicineBody mass indexBioinformaticsEndocrinologyBiologyGeneticsGenetic variantsGenotypeGene

Affiliated Institutions

University of Cambridge GB

Related Publications

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Stephen Burgess , Adam S. Butterworth , Simon G. Thompson

ABSTRACT Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potential...

2013 Genetic Epidemiology 5908 citations

The many weak instruments problem and Mendelian randomization

Neil M Davies , Stephanie von Hinke , Helmut Farbmacher +3 more

Instrumental variable estimates of causal effects can be biased when using many instruments that are only weakly associated with the exposure. We describe several techniques to ...

2014 Statistics in Medicine 145 citations

Use of Mendelian randomisation to assess potential benefit of clinical intervention

Stephen Burgess , Adam S. Butterworth , Anders Mälarstig +1 more

Mendelian randomisation is a technique for assessing causal associations in observational data. Genetic variants associated with the risk factor of interest are regarded in a si...

2012 BMJ 299 citations

Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome

Giulio Marchesini , Elisabetta Bugianesi , Gabriele Forlani +8 more

Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin–resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set. ...

2003 Hepatology 2654 citations

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

George Davey Smith , Gibran Hemani

Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of ...

2014 Human Molecular Genetics 4717 citations

Publication Info

Year: 2014
Type: article
Volume: 9
Issue: 10
Pages: e108891-e108891
Citations: 101
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

101

OpenAlex

Cite This

APA Style

                            
                                
                                    Stephen Burgess, 
                                
                                    Daniel F. Freitag, 
                                
                                    Hassan Khan
                                
                                et al.
                            
                            (2014). 
                            Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions. 
                            PLoS ONE
                            , 9
                            (10)
                            , e108891-e108891.
                            https://doi.org/10.1371/journal.pone.0108891
                        

Identifiers

DOI: 10.1371/journal.pone.0108891