Abstract
Virus-like particles (VLPs) are self-assembling, non-replicating particles lacking the viral genome that are formed by one or several viral structural proteins. VLPs can be purified after expression in yeast cells, insect cells using baculoviruses, Escherichia coli or mammalian cells. Recently, vaccines based on VLPs have come into focus with the FDA approval of a VLP-based vaccine against human papilloma viruses. However, this application of VLPs is just one of many developments within the VLP field. Other potential applications under development besides vaccines against viruses or cancers also include gene delivery and treatment of different disorders.
Keywords
Virus-like particleVirologyVirusVaccinationBiologyGenetic enhancementImmune systemGeneGene deliveryGenomeImmunologyRecombinant DNAGenetics
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Publication Info
- Year
- 2007
- Type
- review
- Volume
- 7
- Issue
- 7
- Pages
- 997-1007
- Citations
- 92
- Access
- Closed
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Cite This
Torbjörn Ramqvist,
Kalle Andreasson,
Tina Dalianis
(2007).
Vaccination, immune and gene therapy based on virus-like particles against viral infections and cancer.
Expert Opinion on Biological Therapy
, 7
(7)
, 997-1007.
https://doi.org/10.1517/14712598.7.7.997
Identifiers
- DOI
- 10.1517/14712598.7.7.997