Variations on a Theme: Cataloging Human DNA Sequence Variation

Francis S. Collins; Mark S. Guyer; Aravinda Chakravarti

doi:10.1126/science.278.5343.1580

Abstract

New methods for the discovery and scoring of single-nucleotide polymorphisms (SNPs) offer the potential for considerably improved methods for genetic analysis of complex biological phenomena, particularly common diseases. In this Policy Forum, the authors call for a publicly supported effort to discover a large number of SNPs and to place the information in public databases. Participation in this public effort by the private sector would be particularly desirable.

Keywords

CatalogingVariation (astronomy)Sequence (biology)BiologyTheme (computing)DNAComputational biologyGeneticsHuman genetic variationHuman genomeDNA sequencingEvolutionary biologyWorld Wide WebComputer scienceGenomeGene

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Publication Info

Year: 1997
Type: article
Volume: 278
Issue: 5343
Pages: 1580-1581
Citations: 1052
Access: Closed

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APA Style

                            
                                    Francis S. Collins, 
                                
                                    Mark S. Guyer, 
                                
                                    Aravinda Chakravarti
                                
                            (1997). 
                            Variations on a Theme: Cataloging Human DNA Sequence Variation. 
                            Science
                            , 278
                            (5343)
                            , 1580-1581.
                            https://doi.org/10.1126/science.278.5343.1580

Identifiers

DOI: 10.1126/science.278.5343.1580