Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress

Mirella Gouverneur; Bernard M. van den Berg; Max Nieuwdorp; Erik S.G. Stroes; Hans Vink

doi:10.1111/j.1365-2796.2006.01625.x

Abstract

Abstract. The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagulation and leucocyte adhesion, by contributing to the vascular permeability barrier and by mediating shear stress‐induced NO release. In this review, we will focus on the relationship between fluid shear stress and the endothelial glycocalyx. We will address the hypothesis that modulation of glycocalyx synthesis by fluid shear stress may contribute to thinner glycocalyces, and therefore more vulnerable endothelium, at lesion‐prone sites of arterial bifurcations. Finally, we will discuss the effects of known atherogenic stimuli such as hyperglycaemia on whole body glycocalyx volume in humans and its effect on endothelial function.

Keywords

GlycocalyxShear stressEndotheliumMedicineVascular permeabilityEndothelial stem cellCell biologyBiophysicsInternal medicineImmunologyIn vitroBiologyMaterials scienceBiochemistry

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Publication Info

Year: 2006
Type: article
Volume: 259
Issue: 4
Pages: 393-400
Citations: 186
Access: Closed

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APA Style

                            
                                
                                    Mirella Gouverneur, 
                                
                                    Bernard M. van den Berg, 
                                
                                    Max Nieuwdorp
                                
                                et al.
                            
                            (2006). 
                            Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress. 
                            Journal of Internal Medicine
                            , 259
                            (4)
                            , 393-400.
                            https://doi.org/10.1111/j.1365-2796.2006.01625.x
                        

Identifiers

DOI: 10.1111/j.1365-2796.2006.01625.x