Abstract

Skin-Deep Raman Spectroscopy Raman spectroscopy allows for molecular identification via vibrational spectra at optical wavelengths. However, if the optical signal is scattered, as occurs when trying to image tissue, the signal becomes very weak, and it becomes difficult to image a sample with high time resolution. Saar et al. (p. 1368 ) now show that by improving the optics and electronics of the acquisition of the backscattered signal, stimulated Raman scattering spectroscopy can be performed at video rates on human skin, which should enable label-free studies of tissues and, for example, the tracking of the delivery of a drug.

Keywords

Raman spectroscopyRaman scatteringSIGNAL (programming language)OpticsSpectroscopyMaterials scienceCoherent anti-Stokes Raman spectroscopyResolution (logic)WavelengthOptoelectronicsComputer sciencePhysicsArtificial intelligence

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Publication Info

Year
2010
Type
article
Volume
330
Issue
6009
Pages
1368-1370
Citations
821
Access
Closed

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Brian G. Saar, Christian W. Freudiger, Jay R. Reichman et al. (2010). Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering. Science , 330 (6009) , 1368-1370. https://doi.org/10.1126/science.1197236

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DOI
10.1126/science.1197236