Whole exome sequencing identifies rare variants involved in PPIX-metabolizing pathway in anti-TB drug-induced hepatitis

Yu Wu; Lihuan Lu; Fei Wang; Mei‐Ling Zhang; Ruina Chen; Jing-Ru C. Cheng; Xiaomin He; Hongqiu Pan; Honggang Yi; Shaowen Tang

doi:10.1080/14622416.2025.2600244

Abstract

NCOA3 rs2230782 is associated with AT-DIH in Chinese anti-tuberculosis patients.

Keywords

Whole exome sequencinganti- tuberculosis treatmentdrug-induced hepatitisnuclear receptor coactivator 3protoporphyrin IXrare variants

Affiliated Institutions

Related Publications

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Naiyer A. Rizvi , Matthew D. Hellmann , Alexandra Snyder +21 more

Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are revolutionizing cancer treatment. To unravel the genomic determinants of response to this...

2015 Science 7740 citations

Genomic correlates of clinical outcome in advanced prostate cancer

Wassim Abida , Joanna Cyrta , Glenn Heller +40 more

Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known about the impact of...

2019 Proceedings of the National Academy o... 1301 citations

Molecular Determinants of Response to Anti–Programmed Cell Death (PD)-1 and Anti–Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non–Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing

Hira Rizvi , Francisco Sánchez-Vega , Konnor La +29 more

Purpose Treatment of advanced non–small-cell lung cancer with immune checkpoint inhibitors (ICIs) is characterized by durable responses and improved survival in a subset of pati...

2018 Journal of Clinical Oncology 1371 citations

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Ángel García-Díaz , Daniel Sanghoon Shin , Blanca Homet Moreno +16 more

PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important ...

2017 Cell Reports 1773 citations

Exercise and Toll-like receptors.

Michael Gleeson , Brian K. McFarlin , Michael G. Flynn

Toll-like receptors (TLRs) are highly conserved trans-membrane proteins that play an important role in the detection and recognition of microbial pathogens. The key product of T...

2006 PubMed 253 citations

Publication Info

Year: 2025
Type: article
Pages: 1-9
Citations: 0
Access: Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric

Whole exome sequencing identifies rare variants involved in PPIX-metabolizing pathway in anti-TB drug-induced hepatitis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Influential

Cite This

APA Style

                            
                                    Yu Wu, 
                                
                                    Lihuan Lu, 
                                
                                    Fei Wang
                                
                                et al.
                            
                            (2025). 
                            Whole exome sequencing identifies rare variants involved in PPIX-metabolizing pathway in anti-TB drug-induced hepatitis. 
                            Pharmacogenomics
                            
                            , 1-9.
                            https://doi.org/10.1080/14622416.2025.2600244

Identifiers

DOI: 10.1080/14622416.2025.2600244
PMID: 41367266

Data Quality

Data completeness: 77%