Abstract

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.

Keywords

Wnt signaling pathwayCateninBiologyFunction (biology)LRP6DiseaseCancerBioinformaticsCancer researchSignal transductionComputational biologyMedicineCell biologyGeneticsPathology

MeSH Terms

AnimalsHumansNeoplasm ProteinsNeoplasmsWnt ProteinsWnt Signaling Pathwaybeta Catenin

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Publication Info

Year
2022
Type
review
Volume
7
Issue
1
Pages
3-3
Citations
1885
Access
Closed

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Cite This

Jiaqi Liu, Qing Xiao, Jiani Xiao et al. (2022). Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduction and Targeted Therapy , 7 (1) , 3-3. https://doi.org/10.1038/s41392-021-00762-6

Identifiers

DOI
10.1038/s41392-021-00762-6
PMID
34980884
PMCID
PMC8724284

Data Quality

Data completeness: 86%