Abstract
The combination of an advanced scientific understanding of tissue repair and regeneration and the identification of knowledge gaps and the limitations of past clinical trials will provide a strong basis to advance viable clinical approaches for treating patients with wound-healing pathologies.
Keywords
Regeneration (biology)Wound healingMedicineTissue repairDiseaseIntensive care medicineAngiogenesisBioinformaticsInflammationTranslational researchPathologyBiologyImmunologyCancer researchCell biology
MeSH Terms
AgingAnimalsBiomarkersCicatrixFibrosisHumansInfectionsInflammationMiceNeovascularizationPathologicPeptide HydrolasesRegenerationSignal TransductionSkinStem CellsTranslational ResearchBiomedicalWound Healing
Affiliated Institutions
Related Publications
Integrins and other cell adhesion molecules
Cell‐cell and cell‐substratum interactions are mediated through several different families of receptors. In addition to targeting cell adhesion to specific extracellular matrix ...
Re-epithelialization and immune cell behaviour in an ex vivo human skin model
A large body of literature is available on wound healing in humans. Nonetheless, a standardized ex vivo wound model without disruption of the dermal compartment has not been put...
Translational Science and Evidence-Based Healthcare: A Clarification and Reconceptualization of How Knowledge Is Generated and Used in Healthcare
The importance of basing health policy and health care practices on the best available international evidence (“evidence-based health care”) and on translating knowledge or evid...
Biological aspects of macrophage-stimulating protein (MSP) and its receptor.
Macrophage-stimulating protein (MSP; also known as HGF-like protein [HGFl]) is a 78 kDa plasma protein that is secreted by the liver into the circulation as single-chain, biolog...
Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum
The International Diabetes Federation estimates that 415 million adults worldwide now have diabetes and 318 million have impaired glucose tolerance. These numbers are expected t...
Publication Info
- Year
- 2014
- Type
- review
- Volume
- 6
- Issue
- 265
- Pages
- 265sr6-265sr6
- Citations
- 3126
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
3126
OpenAlex
67
Influential
2749
CrossRef
Cite This
Sabine A. Eming,
Paul Martin,
Marjana Tomic‐Canic
(2014).
Wound repair and regeneration: Mechanisms, signaling, and translation.
Science Translational Medicine
, 6
(265)
, 265sr6-265sr6.
https://doi.org/10.1126/scitranslmed.3009337
Identifiers
- DOI
- 10.1126/scitranslmed.3009337
- PMID
- 25473038
- PMCID
- PMC4973620