Keywords
BiologyChromosomeGeneticsX-inactivationDNA replicationDNAMechanism (biology)DNA methylationCell biologyComputational biologyX chromosomeGeneGene expression
Affiliated Institutions
Related Publications
DNA hypomethylation can activate Xist expression and silence X-linked genes.
Xist and other X-linked gene expression was examined by fluorescence in situ hybridization in cells of wild type and DNA methyltranferase (Dnmt) mutant embryos and embryonic ste...
Loss of methylation activates Xist in somatic but not in embryonic cells.
The mouse Xist gene, which is expressed only from the inactive X chromosome, is thought to play a role in the initiation of X inactivation. The 5' end of this gene is fully meth...
DNA methylation patterns and epigenetic memory
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns ar...
X inactivation, differentiation, and DNA methylation
A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic ce...
The Role of DNA Methylation in Mammalian Epigenetics
Genes constitute only a small proportion of the total mammalian genome, and the precise control of their expression in the presence of an overwhelming background of noncoding DN...
Publication Info
- Year
- 1992
- Type
- review
- Volume
- 8
- Issue
- 5
- Pages
- 169-174
- Citations
- 327
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
327
OpenAlex
Cite This
Arthur D. Riggs,
Gerd P. Pfeifer
(1992).
X-chromosome inactivation and cell memory.
Trends in Genetics
, 8
(5)
, 169-174.
https://doi.org/10.1016/0168-9525(92)90219-t
Identifiers
- DOI
- 10.1016/0168-9525(92)90219-t