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The Pfam Protein Families Database

Alex Bateman , Ewan Birney , Lorenzo Cerruti +7 more

Pfam is a large collection of protein multiple sequence alignments and profile hidden Markov models. Pfam is available on the World Wide Web in the UK at http://www.sanger.ac.uk...

2002 Nucleic Acids Research 14207 citations

The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons

Diane Podsiadlo , Sandra Richardson

This study evaluated a modified, timed version of the “Get‐Up and Go” Test (Mathias et al, 1986) in 60 patients referred to a Geriatric Day Hospital (mean age 79.5 years). The p...

1991 Journal of the American Geriatrics So... 13643 citations

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L James , Degu Abate , Kalkidan Hassen Abate +97 more

2018 The Lancet 13391 citations

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J L Murray , Kevin S Ikuta , Fablina Sharara +97 more

2022 The Lancet 13318 citations

APACHE II

William A. Knaus , Elizabeth A. Draper , Douglas P. Wagner +1 more

This paper presents the form and validation results of APACHE II, a severity of disease classification system. APACHE II uses a point score based upon initial values of 12 routi...

1985 Critical Care Medicine 13245 citations

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Theo Vos , Amanuel Alemu Abajobir , Kalkidan Hassen Abate +97 more

2017 The Lancet 13226 citations

Sorafenib in Advanced Hepatocellular Carcinoma

Josep M. Llovet , Sergio Ricci , Vincenzo Mazzaferro +21 more

In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than f...

2008 New England Journal of Medicine 12659 citations

<i>Planck</i> 2018 results

N. Krachmalnicoff , M. Kunz , H. Kurki‐Suonio +97 more

We present cosmological parameter results from the final full-mission Planck measurements of the cosmic microwave background (CMB) anisotropies, combining information from the t...

2020 Astronomy and Astrophysics 12547 citations

The expression of the emotions in man and animals.

Charles Darwin

Acknowledgments List of Illustrations Figures Plates Preface to the Anniversary Edition by Paul Ekman Preface to the Third Edition by Paul Ekman Preface to the Second Edition by...

1872 John Murray eBooks 11363 citations