Going from evidence to recommendations
The GRADE system classifies recommendations made in guidelines as either strong or weak. This article explores the meaning of these descriptions and their implications for patie...
Publications
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307 publications
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2
Background— Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vaso...
Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents
This Clinical Report was retired October 2012. Rickets in infants attributable to inadequate vitamin D intake and decreased exposure to sunlight continues to be reported in the ...
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutra...
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
Citation: Schünemann, H. J. et al. (2008). 'Grading quality of evidence and strength of recommendations for diagnostic tests and strategies', BMJ 336 (7653), 1106-1110. [Availab...
Overdiagnosis in Cancer
This article summarizes the phenomenon of cancer overdiagnosis-the diagnosis of a "cancer" that would otherwise not go on to cause symptoms or death. We describe the two prerequ...
GeneMark.hmm: new solutions for gene finding
The number of completely sequenced bacterial genomes has been growing fast. There are computer methods available for finding genes but yet there is a need for more accurate algo...
Structure and Interpretation of Computer Programs
"The Structure and Interpretation of Computer Programs" is the entry-level subject in Computer Science at the Massachusetts Institute of Technology. It is required of all studen...
The interpretation of a moving retinal image
It is shown that from a monocular view of a rigid, textured, curved surface it is possible, in principle, to determine the gradient of the surface at any point, and the motion o...
New developments in the Inorganic Crystal Structure Database (ICSD): accessibility in support of materials research and design
The materials community in both science and industry use crystallographic data models on a daily basis to visualize, explain and predict the behavior of chemicals and materials....