Symmetry Breaking in Non-Abelian Gauge Theories
According to the Goldstone theorem, any manifestly covariant broken-symmetry theory must exhibit massless particles. However, it is known from previous work that such particles ...
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608 publications
A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
Defective Gene Detective Identifying genes that give rise to diseases is one of the major goals of sequencing human genomes. However, putative loss-of-function genes, which are ...
Error filtering, pair assembly and error correction for next-generation sequencing reads
Abstract Motivation: Next-generation sequencing produces vast amounts of data with errors that are difficult to distinguish from true biological variation when coverage is low. ...
Allele-specific copy number analysis of tumors
We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis...
An Investigation into the Determinants of Customer Satisfaction
The authors investigate whether it is necessary to include disconfirmation as an intervening variable affecting satisfaction as is commonly argued, or whether the effect of disc...
The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression
As defined by the DSM-IV, BPD is highly heritable. There are substantial genetic and nonshared environmental correlations between mania and depression, but most of the genetic v...
Nested clade analyses of phylogeographic data: testing hypotheses about gene flow and population history
Since the 1920s, population geneticists have had measures that describe how genetic variation is distributed spatially within a species’ geographical range. Modern genetic surve...
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Significance Coronaviruses such as Middle East respiratory syndrome coronavirus (MERS-CoV) cause severe respiratory distress with high fatality rates. The spike (S) glycoprotein...
Positive Natural Selection in the Human Lineage
Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species. Until re...
Psychological resources, positive illusions, and health.
Psychological beliefs such as optimism, personal control, and a sense of meaning are known to be protective of mental health. Are they protective of physical health as well? The...
Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality
The aging and growth of the population resulted in an increase in global cardiovascular deaths between 1990 and 2013, despite a decrease in age-specific death rates in most regi...
Graphene segregated on Ni surfaces and transferred to insulators
We report an approach to synthesize high quality graphene by surface segregation and substrate transfer. Graphene was segregated from Ni surface under the ambient pressure by di...