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An Agenda for Purely Confirmatory Research
The veracity of substantive research claims hinges on the way experimental data are collected and analyzed. In this article, we discuss an uncomfortable fact that threatens the ...
Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells
GPI-linked protein molecules become Triton-insoluble during polarized sorting to the apical cell surface of epithelial cells. These insoluble complexes, enriched in cholesterol,...
Expander codes
Using expander graphs, we construct a new family of asymptotically good, linear error-correcting codes. These codes have linear time sequential decoding algorithms and logarithm...
Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocardit...
Optimal surface reconstruction from planar contours
In many scientific and technical endeavors, a three-dimensional solid must be reconstructed from serial sections, either to aid in the comprehension of the object's structure or...
Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe
Abstract Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-calorie diet have been recognized as major risk factors for the most common...
BEAGLE: An Application Programming Interface and High-Performance Computing Library for Statistical Phylogenetics
Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest i...
Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns.
To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discorda...
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
Alzheimer's disease (AD), the most common neurodegenerative disorder, is a growing public health problem and still lacks effective treatments. Recent evidence suggests that micr...
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET
The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during...
The substantia nigra of the human brain
Parkinson's disease is characterized by massive degeneration of dopamine-containing neurons in the midbrain. However, the vulnerability of these neurons is heterogeneous both ac...