Publications
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The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amin...
9. Pharmacologic Approaches to Glycemic Treatment: <i>Standards of Medical Care in Diabetes—2022</i>
The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide the compo...
oncoPredict: an R package for predicting <i>in vivo</i> or cancer patient drug response and biomarkers from cell line screening data
Abstract Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of...
Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
ContextHypertension is associated with a significantly increased risk of morbidity and mortality. Only diuretics and β-blockers have been shown to reduce this risk in long-term ...
Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer
Enzalutamide was associated with significantly longer progression-free and overall survival than standard care in men with metastatic, hormone-sensitive prostate cancer receivin...
Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19
Our study confirmed previous observations suggesting that underlying cardiovascular disease is associated with an increased risk of in-hospital death among patients hospitalized...
A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors
We conducted a randomized, double-blind, placebo-controlled trial of postoperative therapy with tamoxifen (10 mg twice a day) in 2644 patients with breast cancer, histologically...
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
A full-length clone coding for the rat alpha 7 nicotinic receptor subunit was isolated from an adult brain cDNA library and expressed in Xenopus oocytes. A significant proportio...