Neuropathologic Features of Amnestic Mild Cognitive Impairment
The neuropathologic features of aMCI matched the clinical features and seemed to be intermediate between the neurofibrillary changes of aging and the pathologic features of very...
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Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections
Selective and sensitive silver staining of extracellular amyloid deposits and intraneuronal neurofibrillary changes can be applied to 50–150 μ.m thick polyethylene glycol sectio...
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
These data suggest that mild cognitive impairment may be the earliest clinical manifestation of common age-related neurologic diseases.
Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies
These findings indicate that brain metabolism as assessed by FDG PET during mental rest is a sensitive marker of disease progression in Alzheimer's disease over a 1-year period....
Neuropathologic Substrate of Mild Cognitive Impairment
In patients with amnestic MCI who were followed longitudinally, the early changes of Alzheimer disease were present. The NFTs were slightly more prominent than beta-amyloid pept...
The Fluorodeoxyglucose 18F Scan in Alzheimer's Disease and Multi-infarct Dementia
• Patients with Alzheimer's disease and multi-infarct dementia were studied with scans using fluorodeoxyglucose tagged with fluorine 18. The rates of glucose metabolism were cal...
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease
Accumulation of amyloid-beta (Abeta) is one of the earliest molecular events in Alzheimer disease (AD), whereas tau pathology is thought to be a later downstream event. It is no...
Clinically diagnosed Alzheimer's disease: Autopsy results in 150 cases
Abstract One hundred fifty autopsy brains from patients with clinically diagnosed Alzheimer's disease (AD) were examined pathologically. The brains were received consecutively o...