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Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse...
First published in 1967, Professor Batchelor's classic text on fluid dynamics is still one of the foremost texts in the subject. The careful presentation of the underlying theor...
Abstract We describe a series of stages for development of the embryo of the zebrafish, Danio (Brachydanio) rerio . We define seven broad periods of embryogenesis—the zygote, cl...
Abstract In a 1935 paper and in his book Theory of Probability, Jeffreys developed a methodology for quantifying the evidence in favor of a scientific theory. The centerpiece wa...
The HER-2/ neu oncogene is a member of the erb B-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be...
Crossing the boundaries in global sustainability The planetary boundary (PB) concept, introduced in 2009, aimed to define the environmental limits within which humanity can safe...
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this...
Continuing population and consumption growth will mean that the global demand for food will increase for at least another 40 years. Growing competition for land, water, and ener...
Trastuzumab increases the clinical benefit of first-line chemotherapy in metastatic breast cancer that overexpresses HER2.
STANDARD CRITERIA FOR TOXICITY and for response to treatment are important prerequisites to the conduct of cancer trials. The Eastern Cooperative Oncology Group criteria for tox...