The substantia nigra of the human brain
To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D(28K) immunosta...
Publications
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146 publications
Supplementary motor area and other cortical areas in organization of voluntary movements in man
1. Previous studies in man have revealed a coupling between the regional cerebral blood flow (rCBF) and the regional cerebral metabolic rate for oxygen. In normal man, increases...
Tau is a candidate gene for chromosome 17 frontotemporal dementia
Abstract Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP‐17), a recently defined disease entity, is clinically characterized by personality changes sometimes...
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis
We compared MRI criteria used to predict conversion of suspected multiple sclerosis to clinically definite multiple sclerosis. Seventy-four patients with clinically isolated neu...
Establishing rigour in qualitative research: the decision trail
The aim of this paper is to show the way in which the decision trail of a qualitative research process can be maintained. It is argued that the trustworthiness (rigour) of a stu...
Rape Trauma Syndrome
The authors interviewed and followed 146 patients admitted during a one-year period to the emergency ward of a city hospital with a presenting complaint of having been raped. Ba...
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
A molecular basis for memory failure in Alzheimer's disease (AD) has been recently hypothesized, in which a significant role is attributed to small, soluble oligomers of amyloid...
The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*
The Campaign was associated with sustained, continuous quality improvement in sepsis care. Although not necessarily cause and effect, a reduction in reported hospital mortality ...
Early Lactate-Guided Therapy in Intensive Care Unit Patients
In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consis...
Survey Questions: Handcrafting the Standardized Questionnaire
This book reviews the experimental literature on how survey questions behave as well as the lore of professional experience and culls from them those guiding principles and spec...