Cancer immunotherapy using checkpoint blockade
The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses i...
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507 publications
World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)
An unprecedented outbreak of pneumonia of unknown aetiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus was identified as the causative ...
UniProt: the Universal Protein Knowledgebase in 2023
Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional inf...
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
This review is an updated and expanded version of the five prior reviews that were published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic ag...
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy
In this case series of critically ill patients with laboratory-confirmed COVID-19 admitted to ICUs in Lombardy, Italy, the majority were older men, a large proportion required m...
30 Years of Lithium‐Ion Batteries
Abstract Over the past 30 years, significant commercial and academic progress has been made on Li‐based battery technologies. From the early Li‐metal anode iterations to the cur...
ISOLATION BY DISTANCE
important S line of attack on the evolutionary problem.While such differences can only rarely represent first steps toward speciation in the sense of the splitting of the specie...
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCO...