Publications
Explore 1,888 academic publications
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
Alzheimer's disease (AD), the most common neurodegenerative disorder, is a growing public health problem and still lacks effective treatments. Recent evidence suggests that micr...
Genetic influence on neurogenesis in the dentate gyrus of adult mice
To address genetic influences on hippocampal neurogenesis in adult mice, we compared C57BL/6, BALB/c, CD1(ICR), and 129Sv/J mice to examine proliferation, survival, and differen...
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
sorLA (sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons. Its homology to sorting receptors that shuttle between th...
Astrogliosis
In addition to their many functions in the healthy central nervous system (CNS), astrocytes respond to CNS damage and disease through a process called astrogliosis. For many dec...
High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.
Antitumor monoclonal antibodies must bind to tumor antigens with high affinity to achieve durable tumor retention. This has spurred efforts to generate high affinity antibodies ...
Experience-dependent modification of synaptic plasticity in visual cortex
In many regions of the cerebral cortex, Ca2+ influx through NMDA (N-methyl-D-aspartate) sensitive glutamate receptors (NMDA receptors) can trigger two forms of synaptic plastici...
Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms
A reduced blood or oxygen supply to the brain leads to neuronal death caused by excessive activation of glutamate receptors. Recent evidence suggests that two distinct phases of...
Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry.
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental ac...